BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSP90AA1
86kDa, 89kDa, AL024080, AL024147, Hsp86-1, Hsp89, Hsp90, Hspca, hsp4, RP23-60K23.1
heat shock protein 90, alpha (cytosolic), class A member 1
GO Process (13)
GO Function (20)
GO Component (18)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [ISO]
- nitric oxide biosynthetic process [TAS]
- positive regulation of cell size [ISO]
- positive regulation of cytotoxic T cell differentiation [TAS]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of protein import into nucleus, translocation [ISO]
- protein import into mitochondrial outer membrane [ISO]
- protein refolding [TAS]
- regulation of catalytic activity [ISO]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
- ATP binding [ISO]
- ATPase activity [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [ISO]
- TPR domain binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- identical protein binding [ISO]
- ion channel binding [ISO]
- mRNA binding [ISO]
- nitric-oxide synthase regulator activity [IDA, ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- sulfonylurea receptor binding [ISO]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- brush border membrane [ISO]
- cell surface [ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO, TAS]
- extracellular matrix [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IDA]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [IDA]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID