BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NPM1
B23, NO38, Npm, RP23-323L8.2
nucleophosmin 1
GO Process (39)
GO Function (18)
GO Component (16)
Gene Ontology Biological Process
- DNA repair [ISO]
- cell aging [ISO]
- cell growth [IDA]
- cell volume homeostasis [IDA, IMP]
- centrosome cycle [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of centrosome duplication [ISO]
- negative regulation of mRNA splicing, via spliceosome [IDA]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [ISO]
- nucleocytoplasmic transport [IDA, ISO]
- nucleosome assembly [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cellular biosynthetic process [IDA, IMP]
- positive regulation of centrosome duplication [IGI]
- positive regulation of protein kinase activity [IDA]
- positive regulation of translation [ISO]
- protein destabilization [IMP]
- protein homooligomerization [ISO]
- protein localization [IMP, ISO]
- protein oligomerization [ISO]
- rRNA export from nucleus [IDA, IMP]
- regulation of DNA damage response, signal transduction by p53 class mediator [IGI]
- regulation of cell cycle [IMP]
- regulation of centriole replication [ISO]
- regulation of centrosome duplication [IMP]
- regulation of eIF2 alpha phosphorylation by dsRNA [ISO]
- regulation of endodeoxyribonuclease activity [ISO]
- regulation of endoribonuclease activity [ISO]
- regulation of neuron apoptotic process [ISO]
- response to stress [ISO]
- ribosomal large subunit biogenesis [IDA, IMP]
- ribosomal large subunit export from nucleus [IMP]
- ribosomal small subunit biogenesis [IDA, IMP]
- ribosomal small subunit export from nucleus [IDA]
Gene Ontology Molecular Function- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
- DNA binding [ISO]
- NF-kappaB binding [ISO]
- RNA binding [IDA, ISO]
- Tat protein binding [ISO]
- enzyme binding [ISO]
- histone binding [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein kinase inhibitor activity [ISO]
- rRNA binding [IDA]
- ribosomal large subunit binding [ISO]
- ribosomal small subunit binding [ISO]
- transcription coactivator activity [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- cell [IMP]
- centrosome [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- focal adhesion [ISO]
- granular component [IDA]
- intracellular [IMP]
- large ribosomal subunit [IDA]
- membrane [ISO]
- nuclear speck [IDA]
- nucleolus [IDA, ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- ribonucleoprotein complex [ISO]
- small ribosomal subunit [IDA]
- spindle pole centrosome [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID