BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KCNJ2
IRK1, Kcnf1, Kir2.1, RP23-408D5.1
potassium inwardly-rectifying channel, subfamily J, member 2
GO Process (17)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle cell action potential involved in contraction [ISO]
- magnesium ion transport [IDA]
- membrane repolarization during action potential [ISO]
- membrane repolarization during cardiac muscle cell action potential [ISO]
- positive regulation of potassium ion transmembrane transport [ISO]
- potassium ion import [IBA, ISO]
- potassium ion transmembrane transport [ISO]
- potassium ion transport [ISO]
- protein homotetramerization [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of ion transmembrane transport [IBA]
- regulation of membrane repolarization [ISO]
- regulation of skeletal muscle contraction via regulation of action potential [ISO]
- relaxation of cardiac muscle [ISO]
- relaxation of skeletal muscle [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- T-tubule [ISO]
- dendrite [ISO]
- dendritic spine [ISO]
- integral component of plasma membrane [IBA]
- intercalated disc [ISO]
- intrinsic component of membrane [ISO]
- neuronal cell body [ISO]
- plasma membrane [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
- voltage-gated potassium channel complex [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID