BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ARF6
AI788669, AW496366
ADP-ribosylation factor 6
GO Process (17)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- GTP catabolic process [TAS]
- cortical actin cytoskeleton organization [ISO]
- establishment of epithelial cell polarity [IMP]
- hepatocyte apoptotic process [IMP]
- liver development [IMP]
- myeloid cell apoptotic process [IMP]
- negative regulation of dendrite development [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- protein localization to cell surface [IDA]
- protein localization to endosome [IMP, ISO]
- protein transport [TAS]
- regulation of Rac protein signal transduction [ISO]
- regulation of dendritic spine development [IMP, ISO]
- regulation of filopodium assembly [ISO]
- regulation of toll-like receptor 4 signaling pathway [NAS]
- ruffle organization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell cortex [ISO]
- cytoplasm [IDA]
- early endosome [ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO, TAS]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [IDA]
- plasma membrane [IDA, ISO]
- recycling endosome [ISO]
- recycling endosome membrane [ISO]
- ruffle [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID