BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SEMA4D
CD100, Semacl2, Semaj, Semcl2, coll-4
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
GO Process (19)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- leukocyte aggregation [ISO]
- negative regulation of alkaline phosphatase activity [IDA, ISO]
- negative regulation of cell adhesion [ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- ossification involved in bone maturation [IMP, ISO]
- positive regulation of Rho GTPase activity [IMP, ISO]
- positive regulation of axonogenesis [IDA, IGI]
- positive regulation of cell migration [IDA, ISO]
- positive regulation of collateral sprouting [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of cell projection organization [ISO]
- regulation of cell shape [ISO]
- regulation of dendrite morphogenesis [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID