BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CALR
CRT, Calregulin
calreticulin
GO Process (22)
GO Function (13)
GO Component (21)
Gene Ontology Biological Process
- cell cycle arrest [ISO]
- cellular senescence [IMP, ISO]
- chaperone-mediated protein folding [ISO]
- cortical actin cytoskeleton organization [IDA]
- negative regulation of intracellular steroid hormone receptor signaling pathway [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of retinoic acid receptor signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of translation [ISO]
- peptide antigen assembly with MHC class I protein complex [IMP]
- positive regulation of DNA replication [ISO]
- positive regulation of cell cycle [IMP, ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein export from nucleus [ISO]
- protein localization to nucleus [IMP, ISO]
- protein stabilization [IDA]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
- androgen receptor binding [ISO]
- calcium ion binding [IDA, ISO]
- carbohydrate binding [IDA]
- glycoprotein binding [ISO]
- hormone binding [ISO]
- integrin binding [ISO]
- iron ion binding [ISO]
- mRNA binding [IDA, ISO]
- peptide binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- ubiquitin protein ligase binding [ISO]
- unfolded protein binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MHC class I peptide loading complex [IMP]
- acrosomal vesicle [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- endoplasmic reticulum [IDA, ISO, ISS]
- endoplasmic reticulum lumen [IDA, ISO]
- external side of plasma membrane [IDA]
- extracellular matrix [ISO]
- extracellular space [IDA, ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- polysome [IDA]
- protein complex [ISO]
- sarcoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID