BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ANXA1
Anx-1, Anx-A1, C430014K04Rik, Lpc-1, Lpc1
annexin A1
GO Process (25)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- DNA duplex unwinding [ISO]
- DNA rewinding [ISO]
- DNA strand renaturation [ISO]
- alpha-beta T cell differentiation [IMP]
- arachidonic acid secretion [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular response to glucocorticoid stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- insulin secretion [ISO]
- keratinocyte differentiation [ISO]
- negative regulation of interleukin-8 secretion [ISO]
- negative regulation of phospholipase A2 activity [ISO]
- negative regulation of protein secretion [ISO]
- neutrophil clearance [ISO]
- neutrophil homeostasis [IMP, ISO]
- peptide cross-linking [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of neutrophil apoptotic process [IMP]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- prolactin secretion [ISO]
- regulation of cell proliferation [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
- annealing helicase activity [ISO]
- calcium-dependent phospholipid binding [ISO]
- calcium-dependent protein binding [ISO]
- double-stranded DNA-dependent ATPase activity [ISO]
- helicase activity [ISO]
- phospholipase A2 inhibitor activity [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein homodimerization activity [ISO]
- single-stranded DNA binding [ISO]
- single-stranded RNA binding [ISO]
- structural molecule activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID