BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
G6PDX
G28A, G6pd, Gpdx, RP23-436K3.17-003
glucose-6-phosphate dehydrogenase X-linked
GO Process (24)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- NADP biosynthetic process [IDA, IMP]
- NADP metabolic process [ISO]
- NADPH regeneration [ISO]
- angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure [IMP]
- cellular response to oxidative stress [ISO]
- cholesterol biosynthetic process [ISO]
- cytokine production [IMP, ISO]
- erythrocyte development [IMP]
- erythrocyte maturation [ISO]
- glucose 6-phosphate metabolic process [ISO]
- glutathione metabolic process [IMP, ISO]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- negative regulation of protein glutathionylation [ISO]
- oxidation-reduction process [IMP, ISO]
- pentose biosynthetic process [IDA, IMP, ISO]
- pentose-phosphate shunt [ISO]
- pentose-phosphate shunt, oxidative branch [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of neuron apoptotic process [ISO]
- response to ethanol [ISO]
- response to oxidative stress [IMP]
- ribose phosphate biosynthetic process [ISO]
- vasodilation by angiotensin involved in regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID