BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAPGEF2
5830453M24Rik, CNRasGEF, Pdzgef1, RA-GEF-1, mKIAA0313, nRapGEP
Rap guanine nucleotide exchange factor (GEF) 2
GO Process (32)
GO Function (7)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- Rap protein signal transduction [ISO]
- adenylate cyclase-activating adrenergic receptor signaling pathway [ISO]
- blood vessel development [IMP]
- brain-derived neurotrophic factor receptor signaling pathway [ISO]
- cAMP-mediated signaling [IDA, ISO]
- cellular response to cAMP [IDA, IMP, ISO]
- cellular response to cGMP [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- establishment of endothelial barrier [ISO]
- forebrain neuron development [IMP]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of dendrite morphogenesis [IMP, ISO]
- negative regulation of melanin biosynthetic process [IMP]
- nerve growth factor signaling pathway [ISO]
- neuron migration [IMP]
- neuron projection development [IMP, ISO]
- neuropeptide signaling pathway [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP, ISO]
- positive regulation of Rap GTPase activity [IDA, IMP, ISO]
- positive regulation of Ras GTPase activity [IMP, ISO]
- positive regulation of cAMP-dependent protein kinase activity [IMP, ISO]
- positive regulation of cAMP-mediated signaling [ISO]
- positive regulation of dendritic cell apoptotic process [IMP, ISO]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of protein binding [IDA]
- positive regulation of protein kinase activity [IDA, ISO]
- positive regulation of vasculogenesis [IMP]
- regulation of cell junction assembly [ISO]
- regulation of synaptic plasticity [ISO]
- ventricular system development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID