BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PTPN1
PTP-1B, PTP-HA2, PTP1B, RP23-58A8.1
protein tyrosine phosphatase, non-receptor type 1
GO Process (13)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- endoplasmic reticulum unfolded protein response [ISO]
- insulin receptor signaling pathway [IMP]
- negative regulation of ERK1 and ERK2 cascade [IGI]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IGI]
- peptidyl-tyrosine dephosphorylation [IMP, ISO]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IGI]
- platelet-derived growth factor receptor-beta signaling pathway [IMP, ISO]
- protein dephosphorylation [IMP, ISO]
- regulation of endocytosis [ISO]
- regulation of hepatocyte growth factor receptor signaling pathway [ISO]
- regulation of insulin receptor signaling pathway [ISO]
- regulation of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID