BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB10
AW107754
RAB10, member RAS oncogene family
GO Process (17)
GO Function (5)
GO Component (16)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi to plasma membrane transport [ISO]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [ISO]
- axonogenesis [ISO]
- cellular response to insulin stimulus [IMP]
- endoplasmic reticulum tubular network organization [ISO]
- endosomal transport [ISO]
- establishment of neuroblast polarity [ISO]
- establishment of protein localization to endoplasmic reticulum membrane [ISO]
- establishment of protein localization to membrane [ISO]
- intracellular protein transport [TAS]
- protein localization to plasma membrane [IMP]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
- vesicle-mediated transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- cell [TAS]
- endoplasmic reticulum membrane [ISO]
- endoplasmic reticulum tubular network [ISO]
- endosome [ISO]
- endosome membrane [IBA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- insulin-responsive compartment [IBA, ISO]
- intracellular [TAS]
- membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- primary cilium [IDA, ISO]
- recycling endosome [ISO]
- trans-Golgi network [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID