BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BNIP3
Nip3
BCL2/adenovirus E1B interacting protein 3
GO Process (26)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- apoptotic process [ISO]
- autophagic cell death [ISO]
- brown fat cell differentiation [IDA]
- cell death [ISO]
- cellular response to cobalt ion [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to hypoxia [ISO]
- defense response to virus [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to hypoxia [ISO]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial outer membrane permeabilization [IBA, ISO]
- mitochondrial protein catabolic process [ISO]
- negative regulation of membrane potential [ISO]
- negative regulation of mitochondrial fusion [ISO]
- neuron apoptotic process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of programmed cell death [IBA, ISO]
- positive regulation of protein complex disassembly [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- reactive oxygen species metabolic process [ISO]
- regulation of mitochondrial membrane permeability [ISO]
- response to hypoxia [ISO]
- toxin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- dendrite [ISO]
- endoplasmic reticulum [IBA]
- integral component of mitochondrial outer membrane [ISO]
- intracellular [IGI]
- mitochondrial membrane [IDA, ISO]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- neuronal postsynaptic density [IDA]
- nuclear envelope [IBA, ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID