BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
POR
4933424M13Rik, CPR, CYPOR
P450 (cytochrome) oxidoreductase
GO Process (17)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- cellular organofluorine metabolic process [ISO]
- demethylation [ISO]
- fatty acid oxidation [ISO]
- internal peptidyl-lysine acetylation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of lipase activity [ISO]
- nitrate catabolic process [ISO]
- nitric oxide catabolic process [ISO]
- oxidation-reduction process [IMP, ISO]
- positive regulation of cholesterol biosynthetic process [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of monooxygenase activity [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of steroid hormone biosynthetic process [ISO]
- regulation of cholesterol metabolic process [ISO]
- regulation of growth plate cartilage chondrocyte proliferation [ISO]
Gene Ontology Molecular Function- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
Gene Ontology Cellular Component
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID