BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DAG1
D9Wsu13e, DG, Dp427, Dp71
dystroglycan 1
GO Process (17)
GO Function (9)
GO Component (22)
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [ISO]
- Schwann cell development [IMP]
- basement membrane organization [IMP]
- branching involved in salivary gland morphogenesis [IMP]
- calcium-dependent cell-matrix adhesion [ISO]
- commissural neuron axon guidance [IMP]
- cytoskeletal anchoring at plasma membrane [ISO]
- epithelial tube branching involved in lung morphogenesis [IMP]
- membrane protein ectodomain proteolysis [ISO]
- microtubule anchoring [ISO]
- modulation by virus of host morphology or physiology [ISO]
- morphogenesis of an epithelial sheet [IMP]
- myelination in peripheral nervous system [IMP]
- negative regulation of MAPK cascade [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of protein kinase B signaling [ISO]
- nerve maturation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basement membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cell outer membrane [IDA]
- cell-cell adherens junction [ISO]
- cell-cell junction [IDA]
- contractile ring [ISO]
- costamere [ISO]
- cytoplasm [ISO]
- dystroglycan complex [IDA]
- dystrophin-associated glycoprotein complex [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- filopodium [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- membrane raft [IDA]
- node of Ranvier [IMP]
- nucleoplasm [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA, ISO]
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID