BAIT
TMEM173
2610307O08Rik, ERIS, MPYS, Mita, STING
transmembrane protein 173
GO Process (11)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- activation of innate immune response [IMP, ISO]
- cellular response to exogenous dsRNA [ISO]
- cellular response to interferon-beta [IMP]
- defense response to virus [IMP, ISO]
- innate immune response [IMP, ISO]
- interferon-beta production [IMP, ISO]
- positive regulation of defense response to virus by host [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ADAR
AV242451, Adar1, Adar1p110, Adar1p150, mZaADAR
adenosine deaminase, RNA-specific
GO Process (23)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, ISO]
- base conversion or substitution editing [ISO]
- defense response to virus [IMP]
- definitive hemopoiesis [IMP]
- erythrocyte differentiation [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell homeostasis [IMP]
- in utero embryonic development [IMP]
- miRNA loading onto RISC involved in gene silencing by miRNA [ISO]
- negative regulation of RNA interference [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IMP, ISO]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of viral genome replication [IMP]
- osteoblast differentiation [IMP]
- positive regulation of viral genome replication [IMP, ISO]
- pre-miRNA processing [ISO]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- protein export from nucleus [ISO]
- protein import into nucleus [ISO]
- response to interferon-alpha [ISO]
- response to virus [ISO]
- somatic diversification of immune receptors via somatic mutation [IDA]
Gene Ontology Molecular Function
Mus musculus
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING).
Stimulator of interferon genes (STING) mediates cytosolic DNA-induced innate immune signaling via membrane trafficking. The global identification of proteins that spatiotemporally interact with STING will provide a better understanding of its trafficking mechanisms and of STING signaling pathways. Proximity-dependent biotin identification (BioID) is a powerful technology to identify physiologically relevant protein-protein interactions in living cells. However, biotinylated peptides are rarely ... [more]
J Biol Chem Dec. 07, 2019; 295(32);11174-11183 [Pubmed: 32554809]
Throughput
- High Throughput
Additional Notes
- TurboID fused-STING, peptides were filtered at a false discovery rate (FDR) of 1%.
Curated By
- BioGRID