TRIM5
Gene Ontology Biological Process
- activation of innate immune response [IDA]
- defense response to virus [TAS]
- innate immune response [IDA]
- negative regulation of viral entry into host cell [IDA]
- negative regulation of viral release from host cell [IDA]
- pattern recognition receptor signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- protein K63-linked ubiquitination [IDA]
- protein trimerization [IDA]
- regulation of lipopolysaccharide-mediated signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PHB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5? in mitophagy.
The protein TRIM5? has multiple roles in antiretroviral defense, but the mechanisms underlying TRIM5? action are unclear. Here, we employ APEX2-based proteomics to identify TRIM5?-interacting partners. Our proteomics results connect TRIM5 to other proteins with actions in antiviral defense. Additionally, they link TRIM5 to mitophagy, an autophagy-based mode of mitochondrial quality control that is compromised in several human diseases. We ... [more]
Throughput
- Low Throughput
Additional Notes
- Proximity Ligation Assay
Curated By
- BioGRID