BAIT

KBTBD4

BKLHD4, HSPC252
kelch repeat and BTB (POZ) domain containing 4
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TUBB2A

CDCBM5, TUBB, TUBB2, dJ40E16.7
tubulin, beta 2A class IIa
GO Process (3)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V

Medulloblastoma is the most common malignant brain tumour in children. Genomic studies have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for their subgroups, whereas those for non-WNT/non-SHH tumours remain largely elusive. Recent analyses have revealed recurrent in-frame insertions in the ... [more]

Cell Death Differ Apr. 04, 2022; (); [Pubmed: 35379950]

Throughput

  • Low Throughput

Curated By

  • BioGRID