BAIT

KBTBD4

BKLHD4, HSPC252
kelch repeat and BTB (POZ) domain containing 4
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

TUBA4A

H2-ALPHA, TUBA1
tubulin, alpha 4a
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation.

Chen Z, Ioris RM, Richardson S, Van Ess AN, Vendrell I, Kessler BM, Buffa FM, Busino L, Clifford SC, Bullock AN, D'Angiolella V

Medulloblastoma is the most common malignant brain tumour in children. Genomic studies have identified distinct disease subgroups: wnt/wingless (WNT), sonic hedgehog (SHH), and non-WNT/non-SHH, comprising group 3 and group 4. Alterations in WNT and SHH signalling form the pathogenetic basis for their subgroups, whereas those for non-WNT/non-SHH tumours remain largely elusive. Recent analyses have revealed recurrent in-frame insertions in the ... [more]

Cell Death Differ Apr. 04, 2022; (); [Pubmed: 35379950]

Throughput

  • Low Throughput

Curated By

  • BioGRID