BAIT
IKZF3
AIO, AIOLOS, ZNFN1A3, RP11-94L15.2
IKAROS family zinc finger 3 (Aiolos)
GO Process (6)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CACNA1C
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS
calcium channel, voltage-dependent, L type, alpha 1C subunit
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- axon guidance [TAS]
- calcium ion import [IBA]
- calcium ion transport into cytosol [TAS]
- calcium-mediated signaling using extracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL.
Cereblon (CRBN), a substrate receptor of the E3 ubiquitin ligase complex CRL4CRBN, is the target of the small molecules lenalidomide (Len) and avadomide (Ava). Upon binding of the drugs, Aiolos and Ikaros are recruited to the E3 ligase, ubiquitylated and subsequently degraded. In DLBCL cells, Aiolos and Ikaros are direct transcriptional repressors of interferon stimulated genes (ISG) and degradation of ... [more]
Clin Cancer Res May. 18, 2022; (); [Pubmed: 35583604]
Throughput
- Low Throughput
Curated By
- BioGRID