BAIT
E2F4
E2F-4
E2F transcription factor 4, p107/p130-binding
GO Process (9)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- centriole assembly [ISS]
- gene expression [TAS]
- mitotic cell cycle [TAS]
- motile cilium assembly [ISS]
- multi-ciliated epithelial cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS, TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [IDA, TAS]
Homo sapiens
PREY
EEF1A2
EEF1AL, EF-1-alpha-2, EF1A, HS1, STN, STNL
eukaryotic translation elongation factor 1 alpha 2
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.
Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a novel transcriptional activator of cytoprotective autophagy crucial for zinc homeostasis in cancer cells. Gain- and loss-of-function studies showed that E2F4 promoted autophagy in a cell cycle-dependent ... [more]
Autophagy Mar. 06, 2022; ();1-21 [Pubmed: 35253629]
Throughput
- High Throughput
Curated By
- BioGRID