BAIT
ATG5
2010107M05Rik, 3110067M24Rik, AW319544, Apg5l, Atg5l, C88337, Paddy
autophagy related 5
GO Process (23)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- blood vessel remodeling [IMP]
- cellular response to nitrogen starvation [IBA]
- heart contraction [IMP]
- mitochondrion degradation [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative stranded viral RNA replication [IMP]
- nucleophagy [IBA]
- otolith development [IMP]
- positive regulation of mucus secretion [IMP]
- post-translational protein modification [IDA]
- regulation of cilium assembly [IMP]
- regulation of cytokine secretion involved in immune response [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to drug [IMP]
- response to fungus [IMP]
- vasodilation [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PICALM
CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114
phosphatidylinositol binding clathrin assembly protein
GO Process (22)
GO Function (6)
GO Component (18)
Gene Ontology Biological Process
- axonogenesis [IMP, ISO]
- cargo loading into vesicle [ISO]
- cell proliferation [ISO]
- clathrin coat assembly [ISO]
- clathrin-mediated endocytosis [ISO]
- dendrite morphogenesis [IMP, ISO]
- endosomal transport [ISO]
- hemopoiesis [IMP]
- iron ion homeostasis [ISO]
- iron ion import into cell [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of receptor-mediated endocytosis [ISO]
- positive regulation of beta-amyloid formation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [IDA, ISO]
- regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [ISO]
- regulation of endocytosis [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- vesicle-mediated transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- AP-2 adaptor complex [ISO]
- clathrin coat of coated pit [ISO]
- clathrin-coated vesicle [ISO]
- coated pit [IDA, ISO]
- endosome [ISO]
- intracellular [IDA]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neurofibrillary tangle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- postsynaptic membrane [ISO]
- presynaptic membrane [ISO]
- synapse [ISO]
- synaptic vesicle [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.
Autophagosome formation involves the sequential actions of conserved ATG proteins to coordinate the lipidation of the ubiquitin-like modifier Atg8-family proteins at the nascent phagophore membrane. Although the molecular steps driving this process are well understood, the source of membranes for the expanding phagophore and their mode of delivery are only now beginning to be revealed. Here, we have used quantitative ... [more]
Autophagy Rep Apr. 23, 2022; 1(1);88-118 [Pubmed: 35449600]
Throughput
- Low Throughput
Curated By
- BioGRID