BAIT
ATG5
2010107M05Rik, 3110067M24Rik, AW319544, Apg5l, Atg5l, C88337, Paddy
autophagy related 5
GO Process (23)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- blood vessel remodeling [IMP]
- cellular response to nitrogen starvation [IBA]
- heart contraction [IMP]
- mitochondrion degradation [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative stranded viral RNA replication [IMP]
- nucleophagy [IBA]
- otolith development [IMP]
- positive regulation of mucus secretion [IMP]
- post-translational protein modification [IDA]
- regulation of cilium assembly [IMP]
- regulation of cytokine secretion involved in immune response [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to drug [IMP]
- response to fungus [IMP]
- vasodilation [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TOP2A
Top-2, RP23-333D2.5
topoisomerase (DNA) II alpha
GO Process (18)
GO Function (19)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IGI, ISO]
- DNA ligation [ISO]
- DNA topological change [IDA, ISO]
- DNA unwinding involved in DNA replication [IBA]
- apoptotic chromosome condensation [IBA, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome condensation [IMP]
- chromosome segregation [IDA, IMP, ISO]
- embryonic cleavage [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- mitotic DNA integrity checkpoint [IBA]
- mitotic recombination [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of viral genome replication [ISO]
- resolution of meiotic recombination intermediates [IBA]
- sister chromatid segregation [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
- ATP binding [ISO]
- DNA binding [ISO]
- DNA binding, bending [ISO]
- DNA topoisomerase activity [ISO]
- DNA topoisomerase type II (ATP-hydrolyzing) activity [IDA, IGI, ISO]
- DNA-dependent ATPase activity [ISO]
- chromatin binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- magnesium ion binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase C binding [ISO]
- sequence-specific DNA binding [ISO]
- structure-specific DNA binding [ISO]
- ubiquitin binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.
Autophagosome formation involves the sequential actions of conserved ATG proteins to coordinate the lipidation of the ubiquitin-like modifier Atg8-family proteins at the nascent phagophore membrane. Although the molecular steps driving this process are well understood, the source of membranes for the expanding phagophore and their mode of delivery are only now beginning to be revealed. Here, we have used quantitative ... [more]
Autophagy Rep Apr. 23, 2022; 1(1);88-118 [Pubmed: 35449600]
Throughput
- Low Throughput
Curated By
- BioGRID