BAIT
ATG5
2010107M05Rik, 3110067M24Rik, AW319544, Apg5l, Atg5l, C88337, Paddy
autophagy related 5
GO Process (23)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- blood vessel remodeling [IMP]
- cellular response to nitrogen starvation [IBA]
- heart contraction [IMP]
- mitochondrion degradation [IBA]
- negative regulation of apoptotic process [IMP]
- negative regulation of histone H4-K16 acetylation [IMP]
- negative regulation of protein ubiquitination [IMP]
- negative stranded viral RNA replication [IMP]
- nucleophagy [IBA]
- otolith development [IMP]
- positive regulation of mucus secretion [IMP]
- post-translational protein modification [IDA]
- regulation of cilium assembly [IMP]
- regulation of cytokine secretion involved in immune response [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of release of sequestered calcium ion into cytosol [IMP]
- response to drug [IMP]
- response to fungus [IMP]
- vasodilation [IMP]
- ventricular cardiac muscle cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IRAK1
AA408924, IRAK, IRAK-1, IRAK1-S, Il1rak, Plpk, mPLK, RP23-252M19.7
interleukin-1 receptor-associated kinase 1
GO Process (23)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- JNK cascade [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular response to heat [ISO]
- cytokine-mediated signaling pathway [IDA, ISO]
- interleukin-1-mediated signaling pathway [IDA, ISO]
- lipopolysaccharide-mediated signaling pathway [IDA, ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cholesterol efflux [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein autophosphorylation [IDA, ISO]
- protein oligomerization [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of cytokine-mediated signaling pathway [ISO]
- response to interleukin-1 [ISO]
- response to lipopolysaccharide [IDA, ISO]
- response to peptidoglycan [IDA]
- toll-like receptor 2 signaling pathway [IDA, ISO]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.
Autophagosome formation involves the sequential actions of conserved ATG proteins to coordinate the lipidation of the ubiquitin-like modifier Atg8-family proteins at the nascent phagophore membrane. Although the molecular steps driving this process are well understood, the source of membranes for the expanding phagophore and their mode of delivery are only now beginning to be revealed. Here, we have used quantitative ... [more]
Autophagy Rep Apr. 23, 2022; 1(1);88-118 [Pubmed: 35449600]
Throughput
- Low Throughput
Curated By
- BioGRID