BAIT
ARF3
ADP-ribosylation factor 3
GO Process (4)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CXADR
CAR, CAR4/6, HCAR
coxsackie virus and adenovirus receptor
GO Process (17)
GO Function (8)
GO Component (19)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication [ISS]
- actin cytoskeleton reorganization [IDA]
- blood coagulation [TAS]
- cardiac muscle fiber development [ISS]
- cell-cell junction organization [ISS]
- defense response to virus [IDA]
- epithelial structure maintenance [IMP]
- gamma-delta T cell activation [ISS]
- germ cell migration [ISS]
- heart development [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- homotypic cell-cell adhesion [IDA]
- leukocyte migration [TAS]
- mitochondrion organization [ISS]
- neutrophil chemotaxis [IMP]
- regulation of immune response [TAS]
- transepithelial transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- acrosomal vesicle [ISS]
- adherens junction [IDA]
- apicolateral plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cell body [ISS]
- cell junction [IDA]
- cell-cell junction [IDA]
- extracellular space [IDA]
- filopodium [ISS]
- growth cone [ISS]
- integral component of plasma membrane [NAS]
- intercalated disc [IDA]
- membrane raft [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISS]
- nucleoplasm [IDA]
- plasma membrane [IDA, TAS]
- protein complex [IDA]
- tight junction [IDA]
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.
The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle-structure assembly. Here, we have generated a proximity interaction network for the Arf family using the miniTurboID approach combined with TMT-based quantitative mass spectrometry. Our interactome confirmed known interactions and identified many novel interactors that provide leads for defining Arf pathway cell biological ... [more]
EMBO J Jul. 17, 2022; ();e110698 [Pubmed: 35844135]
Throughput
- High Throughput
Additional Notes
- Constitutively active mutant of GTPase fused with miniTurboID was stably expressed in HEK293A cells, followed by miniTurboID experiment and TMT-based mass spectrometry. FDR threshold of 0.05
Curated By
- BioGRID