BAIT
SAR1A
SAR1, SARA1, Sara, masra2, RP11-367H5.4
secretion associated, Ras related GTPase 1A
GO Process (0)
GO Function (0)
GO Component (1)
Gene Ontology Cellular Component
Homo sapiens
PREY
ACVR1B
ACTRIB, ACVRLK4, ALK4, SKR2
activin A receptor, type IB
GO Process (14)
GO Function (11)
GO Component (4)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IDA]
- activin receptor signaling pathway [IDA, IMP]
- extrinsic apoptotic signaling pathway [IMP]
- negative regulation of cell growth [IDA]
- nodal signaling pathway [IGI]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of erythrocyte differentiation [IDA]
- positive regulation of trophoblast cell migration [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
- ATP binding [IDA]
- SMAD binding [IDA]
- activin binding [IDA]
- activin receptor activity, type I [IDA, TAS]
- activin-activated receptor activity [IDA]
- growth factor binding [IPI]
- inhibin binding [IPI]
- protein binding [IPI]
- protein serine/threonine kinase activity [EXP, IDA]
- transmembrane receptor protein serine/threonine kinase activity [NAS]
- ubiquitin protein ligase binding [NAS]
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.
The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle-structure assembly. Here, we have generated a proximity interaction network for the Arf family using the miniTurboID approach combined with TMT-based quantitative mass spectrometry. Our interactome confirmed known interactions and identified many novel interactors that provide leads for defining Arf pathway cell biological ... [more]
EMBO J Jul. 17, 2022; ();e110698 [Pubmed: 35844135]
Throughput
- High Throughput
Additional Notes
- Constitutively active mutant of GTPase fused with miniTurboID was stably expressed in HEK293A cells, followed by miniTurboID experiment and TMT-based mass spectrometry. FDR threshold of 0.05
Curated By
- BioGRID