BAIT
AIMP2
JTV-1, JTV1, P38, PRO0992
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GSTM3
GST5, GSTB, GSTM3-3, GTM3, RP4-735C1.2
glutathione S-transferase mu 3 (brain)
GO Process (9)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cellular detoxification of nitrogen compound [IDA]
- establishment of blood-nerve barrier [TAS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- nitrobenzene metabolic process [IDA]
- response to estrogen [IEP]
- small molecule metabolic process [TAS]
- xenobiotic catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest to control KRAS-driven cancers. Here, we report that AIMP2-DX2, a variant of the tumor suppressor AIMP2 (aminoacyl-tRNA synthetase-interacting multi-functional protein 2), acts as a cancer-specific regulator of KRAS stability, augmenting KRAS-driven tumorigenesis. AIMP2-DX2 specifically binds to the hypervariable region ... [more]
Nat Commun Dec. 11, 2021; 13(1);2572 [Pubmed: 35546148]
Throughput
- High Throughput
Additional Notes
- AIMP2-DX2 variant
Curated By
- BioGRID