BAIT
AIMP2
JTV-1, JTV1, P38, PRO0992
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
GO Process (2)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GSTP1
DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI
glutathione S-transferase pi 1
GO Process (30)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISS]
- central nervous system development [TAS]
- common myeloid progenitor cell proliferation [ISS]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISS]
- negative regulation of JUN kinase activity [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of MAPK cascade [NAS]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [ISS]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of stress-activated MAPK cascade [ISS]
- negative regulation of tumor necrosis factor production [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IC]
- nitric oxide storage [NAS]
- positive regulation of superoxide anion generation [ISS]
- regulation of ERK1 and ERK2 cascade [ISS]
- regulation of stress-activated MAPK cascade [ISS]
- response to reactive oxygen species [ISS]
- small molecule metabolic process [TAS]
- xenobiotic metabolic process [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest to control KRAS-driven cancers. Here, we report that AIMP2-DX2, a variant of the tumor suppressor AIMP2 (aminoacyl-tRNA synthetase-interacting multi-functional protein 2), acts as a cancer-specific regulator of KRAS stability, augmenting KRAS-driven tumorigenesis. AIMP2-DX2 specifically binds to the hypervariable region ... [more]
Nat Commun Dec. 11, 2021; 13(1);2572 [Pubmed: 35546148]
Throughput
- High Throughput
Additional Notes
- AIMP2-DX2 variant
Curated By
- BioGRID