BAIT

AIMP2

JTV-1, JTV1, P38, PRO0992

aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

GO Process (2)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

gene expression [TAS]

tRNA aminoacylation for protein translation [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

DNAJA1

DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, RP11-54K16.1

DnaJ (Hsp40) homolog, subfamily A, member 1

Alzheimer's Disease Project

GO Process (9)

GO Function (7)

GO Component (5)

Gene Ontology Biological Process

negative regulation of JUN kinase activity [IMP]

negative regulation of apoptotic process [IMP]

negative regulation of protein ubiquitination [IDA]

positive regulation of apoptotic process [IMP]

protein folding [TAS]

protein localization to mitochondrion [IMP]

protein refolding [IBA]

regulation of protein transport [IDA]

response to unfolded protein [TAS]

Gene Ontology Molecular Function

G-protein coupled receptor binding [IPI]
Hsp70 protein binding [IDA]
chaperone binding [IDA, IPI]
low-density lipoprotein particle receptor binding [IDA]
protein binding [IPI]
ubiquitin protein ligase binding [IPI]
unfolded protein binding [IBA]

Gene Ontology Cellular Component

cytoplasmic side of endoplasmic reticulum membrane [TAS]

extracellular vesicular exosome [IDA]

ubiquitin ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

Kim DG, Choi Y, Lee Y, Lim S, Kong J, Song J, Roh Y, Harmalkar DS, Lee K, Goo JI, Cho HY, Mushtaq AU, Lee J, Park SH, Kim D, Min BS, Lee KY, Jeon YH, Lee S, Lee K, Kim S

Recent development of the chemical inhibitors specific to oncogenic KRAS (Kirsten Rat Sarcoma 2 Viral Oncogene Homolog) mutants revives much interest to control KRAS-driven cancers. Here, we report that AIMP2-DX2, a variant of the tumor suppressor AIMP2 (aminoacyl-tRNA synthetase-interacting multi-functional protein 2), acts as a cancer-specific regulator of KRAS stability, augmenting KRAS-driven tumorigenesis. AIMP2-DX2 specifically binds to the hypervariable region ... [more]

Nat Commun Dec. 11, 2021; 13(1);2572 [Pubmed: 35546148]

Throughput

High Throughput

Additional Notes

AIMP2-DX2 variant

Curated By

BioGRID