TRPV1
Gene Ontology Biological Process
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, ISO]
- cellular response to ATP [IDA]
- cellular response to alkaloid [IMP]
- cellular response to cytokine stimulus [IDA]
- cellular response to growth factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to temperature stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- detection of chemical stimulus involved in sensory perception of pain [ISO]
- diet induced thermogenesis [ISO]
- fever generation [ISO]
- glutamate secretion [IDA]
- inflammatory response [IEP]
- ion transmembrane transport [ISO]
- lipid metabolic process [ISO]
- microglial cell activation [IMP]
- negative regulation of establishment of blood-brain barrier [IMP]
- peptide secretion [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of gastric acid secretion [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- response to heat [IDA, ISO]
- response to organonitrogen compound [ISO]
- response to pH [IDA, IEP, ISO]
- response to pain [ISO]
- response to peptide hormone [IEP]
- sensory perception of mechanical stimulus [ISO]
- sensory perception of pain [ISO]
- signal transduction [IDA]
- smooth muscle contraction involved in micturition [ISO]
- temperature homeostasis [ISO]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
Gene Ontology Cellular Component
HRH1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- cellular response to histamine [ISS]
- inflammatory response [TAS]
- inositol phosphate-mediated signaling [ISS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [TAS]
- positive regulation of inositol trisphosphate biosynthetic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715-725 and 736-749. Cell-penetrating peptides containing these sequences suppress histamine-induced scratching behavior in a cheek injection model. The H1R-TRPV1 binding is kept at a minimum at rest in mouse trigeminal neurons due ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TRPV1 HRH1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 3413632 |
Curated By
- BioGRID