UBE2I
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRPV1
Gene Ontology Biological Process
- behavioral response to pain [ISO]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IDA, ISO]
- cellular response to ATP [IDA]
- cellular response to alkaloid [IMP]
- cellular response to cytokine stimulus [IDA]
- cellular response to growth factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to temperature stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- detection of chemical stimulus involved in sensory perception of pain [ISO]
- diet induced thermogenesis [ISO]
- fever generation [ISO]
- glutamate secretion [IDA]
- inflammatory response [IEP]
- ion transmembrane transport [ISO]
- lipid metabolic process [ISO]
- microglial cell activation [IMP]
- negative regulation of establishment of blood-brain barrier [IMP]
- peptide secretion [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of gastric acid secretion [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- response to heat [IDA, ISO]
- response to organonitrogen compound [ISO]
- response to pH [IDA, IEP, ISO]
- response to pain [ISO]
- response to peptide hormone [IEP]
- sensory perception of mechanical stimulus [ISO]
- sensory perception of pain [ISO]
- signal transduction [IDA]
- smooth muscle contraction involved in micturition [ISO]
- temperature homeostasis [ISO]
- thermoception [ISO]
- urinary bladder smooth muscle contraction [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
- ATP binding [IDA]
- calcium channel activity [ISO]
- calcium-release channel activity [IMP]
- calmodulin binding [IPI]
- cation channel activity [IDA]
- cation transmembrane transporter activity [IDA]
- chloride channel regulator activity [IDA]
- excitatory extracellular ligand-gated ion channel activity [IDA]
- identical protein binding [IPI]
- ion channel activity [ISO]
- ligand-gated ion channel activity [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- transmembrane signaling receptor activity [IDA]
Gene Ontology Cellular Component
Biochemical Activity (Sumoylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
The molecular mechanism underlying the functional interaction between H1R and TRPV1 remains unclear. We show here that H1R directly binds to the carboxy-terminal region of TRPV1 at residues 715-725 and 736-749. Cell-penetrating peptides containing these sequences suppress histamine-induced scratching behavior in a cheek injection model. The H1R-TRPV1 binding is kept at a minimum at rest in mouse trigeminal neurons due ... [more]
Throughput
- Low Throughput
Additional Notes
- Reaction contains SAE1 and UBA2 [E1], UBE2I [E2] and SUMO1. No E3 enzyme included in reaction. Rat TRPV1 is SUMOylated at K822
Curated By
- BioGRID