GCN5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HMT1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Functional connection between histone acetyltransferase Gcn5p and methyltransferase Hmt1p.
Histone acetylation and methylation are linked to a variety of nuclear activities, most notably transcriptional regulation. Both synergistic and antagonistic relationships between these two modifications have been reported in different systems. Here we show that the budding yeast histone H4 arginine 3 (R3) methyltransferase Hmt1p binds acetylated histones H3 and H4, and importantly, that acetylated H4 is a significantly better ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: toxin resistance (APO:0000215)
Additional Notes
- Deletion of HMT1 in a GCN5 deletion mutant rescues the AT sensitive growth defect
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GCN5 HMT1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.145 | BioGRID | 384287 | |
HMT1 GCN5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -1 | BioGRID | 722001 | |
GCN5 HMT1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 343117 |
Curated By
- BioGRID