SYNCRIP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DHX36
Gene Ontology Biological Process
- ATP catabolic process [IBA, IDA]
- RNA processing [IBA]
- RNA secondary structure unwinding [IDA]
- innate immune response [TAS]
- ossification [ISS]
- positive regulation of telomere maintenance [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of type I interferon production [TAS]
Gene Ontology Molecular Function- ATP-dependent RNA helicase activity [IBA]
- DNA-dependent ATPase activity [IDA]
- G-quadruplex DNA binding [IDA]
- G-quadruplex RNA binding [IMP]
- core promoter binding [IDA]
- double-stranded RNA binding [IDA]
- histone deacetylase binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISS]
- ATP-dependent RNA helicase activity [IBA]
- DNA-dependent ATPase activity [IDA]
- G-quadruplex DNA binding [IDA]
- G-quadruplex RNA binding [IMP]
- core promoter binding [IDA]
- double-stranded RNA binding [IDA]
- histone deacetylase binding [ISS]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- transcription regulatory region DNA binding [ISS]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MDA231 cell line (score 0.662)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SYNCRIP DHX36 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7673 | BioGRID | 3074386 |
Curated By
- BioGRID