BAIT
H2AFY
H2A.y, H2A/y, H2AF12M, H2AFJ, MACROH2A1.1, mH2A1, macroH2A1.2
H2A histone family, member Y
GO Process (11)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- dosage compensation [IDA]
- establishment of protein localization to chromatin [IMP]
- negative regulation of cell cycle G2/M phase transition [IMP]
- negative regulation of gene expression, epigenetic [IMP]
- negative regulation of histone phosphorylation [IMP]
- negative regulation of protein serine/threonine kinase activity [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter [IGI, IMP]
- nucleosome assembly [NAS]
- regulation of cell growth [IGI]
- regulation of chromatin silencing at rDNA [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RPL11
DBA7, GIG34, L11, RP11-223J15.3
ribosomal protein L11
GO Process (17)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- protein localization to nucleus [ISS]
- protein targeting [IMP]
- rRNA processing [IMP]
- ribosomal large subunit biogenesis [IMP]
- translation [NAS, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.721)
Curated By
- BioGRID