BAIT
LDHA
GSD11, HEL-S-133P, LDH1, LDHM, PIG19
lactate dehydrogenase A
GO Process (5)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CTSH
ACC-4, ACC-5, CPSB, minichain
cathepsin H
GO Process (24)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- T cell mediated cytotoxicity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- adaptive immune response [IEP]
- antigen processing and presentation [TAS]
- bradykinin catabolic process [IDA]
- cellular response to thyroid hormone stimulus [IEP]
- dichotomous subdivision of terminal units involved in lung branching [ISS]
- immune response-regulating signaling pathway [IDA]
- membrane protein proteolysis [IDA]
- metanephros development [ISS]
- negative regulation of apoptotic process [ISS]
- neuropeptide catabolic process [IDA]
- positive regulation of angiogenesis [ISS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of epithelial cell migration [ISS]
- positive regulation of gene expression [IDA]
- positive regulation of peptidase activity [IDA]
- protein destabilization [IMP]
- proteolysis [IDA, TAS]
- response to retinoic acid [ISS]
- surfactant homeostasis [IDA]
- zymogen activation [IDA]
Gene Ontology Molecular Function- HLA-A specific activating MHC class I receptor activity [IDA]
- aminopeptidase activity [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA]
- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type peptidase activity [IDA]
- endopeptidase activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- serine-type endopeptidase activity [ISS]
- thyroid hormone binding [IDA]
- HLA-A specific activating MHC class I receptor activity [IDA]
- aminopeptidase activity [IDA]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA]
- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type peptidase activity [IDA]
- endopeptidase activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- serine-type endopeptidase activity [ISS]
- thyroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MDA231 cell line (score 0.661)
Curated By
- BioGRID