BAIT
APP
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- axon cargo transport [ISS]
- axon midline choice point recognition [ISS]
- axonogenesis [ISS]
- blood coagulation [TAS]
- cellular copper ion homeostasis [ISS]
- collateral sprouting in absence of injury [ISS]
- dendrite development [ISS]
- endocytosis [ISS]
- extracellular matrix organization [ISS, TAS]
- innate immune response [TAS]
- ionotropic glutamate receptor signaling pathway [ISS]
- locomotory behavior [ISS]
- mRNA polyadenylation [ISS]
- mating behavior [ISS]
- negative regulation of endopeptidase activity [IDA]
- neuron apoptotic process [IMP]
- neuron projection development [ISS]
- neuron remodeling [ISS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of mitotic cell cycle [ISS]
- protein phosphorylation [ISS]
- regulation of epidermal growth factor-activated receptor activity [ISS]
- regulation of multicellular organism growth [ISS]
- regulation of synapse structure or activity [ISS]
- regulation of translation [ISS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISS]
- axon [ISS]
- cell surface [IDA]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- endosome [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- integral component of membrane [ISS]
- integral component of plasma membrane [TAS]
- intracellular membrane-bounded organelle [IDA]
- membrane raft [IDA]
- nuclear envelope lumen [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- platelet alpha granule lumen [TAS]
- receptor complex [IDA]
- synapse [IDA]
Homo sapiens
PREY
TRADD
Hs.89862
TNFRSF1A-associated via death domain
GO Process (11)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IMP, TAS]
- extrinsic apoptotic signaling pathway via death domain receptors [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- signal transduction [TAS]
- tumor necrosis factor-mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF7 cell line (score 0.701)
Curated By
- BioGRID