BAIT
SERPINE1
PAI, PAI-1, PAI1, PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
GO Process (34)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- angiogenesis [IEP]
- blood coagulation [TAS]
- cellular response to lipopolysaccharide [IMP]
- chronological cell aging [IEP]
- defense response to Gram-negative bacterium [IGI]
- extracellular matrix organization [TAS]
- fibrinolysis [TAS]
- gene expression [TAS]
- negative regulation of blood coagulation [IC]
- negative regulation of cell adhesion mediated by integrin [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- negative regulation of fibrinolysis [IDA]
- negative regulation of plasminogen activation [IDA, IMP]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IDA]
- negative regulation of vascular wound healing [IGI]
- negative regulation of wound healing [IC]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of angiogenesis [IMP]
- positive regulation of blood coagulation [IMP]
- positive regulation of inflammatory response [IGI]
- positive regulation of interleukin-8 production [IMP]
- positive regulation of leukotriene production involved in inflammatory response [IMP]
- positive regulation of monocyte chemotaxis [IMP]
- positive regulation of receptor-mediated endocytosis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of receptor activity [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MCCC1
MCC-B, MCCA
methylcrotonoyl-CoA carboxylase 1 (alpha)
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.666)
Curated By
- BioGRID