BAIT
TXN
TRDX, TRX, TRX1, RP11-427L11.1
thioredoxin
GO Process (17)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- activation of protein kinase B activity [IC]
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- cellular component movement [TAS]
- innate immune response [TAS]
- negative regulation of hydrogen peroxide-induced cell death [IGI]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- oxidation-reduction process [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of protein kinase B signaling [IC]
- regulation of protein import into nucleus, translocation [IDA]
- response to radiation [IDA]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MTHFD1
MTHFC, MTHFD
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
GO Process (5)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.729)
- MCF7 cell line (score 0.806)
Curated By
- BioGRID