BAIT
CD46
AHUS2, MCP, MIC10, TLX, TRA2.10
CD46 molecule, complement regulatory protein
GO Process (14)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- T cell mediated immunity [IMP]
- adaptive immune response [IC]
- innate immune response [TAS]
- interleukin-10 production [IDA]
- negative regulation of gene expression [IDA]
- positive regulation of T cell proliferation [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-10 production [IDA]
- positive regulation of memory T cell differentiation [IDA]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transforming growth factor beta production [IDA]
- regulation of Notch signaling pathway [IDA]
- regulation of complement activation [TAS]
- sequestering of extracellular ligand from receptor [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNK1
HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65
WNK lysine deficient protein kinase 1
GO Process (7)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF7 cell line (score 0.641)
Curated By
- BioGRID