BAIT
FER
FerT, PPP1R74, Pe1Fe10, Pe1Fe13, Pe1Fe3, Pe1Fe6, TYK3
fer (fps/fes related) tyrosine kinase
GO Process (39)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [IBA, ISS]
- Kit signaling pathway [ISS]
- actin cytoskeleton reorganization [ISS]
- cell adhesion [IBA]
- cell differentiation [IBA]
- cell proliferation [IMP]
- cell-cell adhesion mediated by cadherin [ISS]
- cellular response to insulin stimulus [ISS]
- cellular response to macrophage colony-stimulating factor stimulus [IMP]
- cellular response to reactive oxygen species [ISS]
- chemotaxis [IBA]
- cytokine-mediated signaling pathway [IMP]
- diapedesis [ISS]
- extracellular matrix-cell signaling [ISS]
- innate immune response [IBA]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [ISS]
- interleukin-6-mediated signaling pathway [IMP]
- intracellular signal transduction [TAS]
- microtubule cytoskeleton organization [IMP]
- mitotic cell cycle [IMP]
- negative regulation of mast cell activation involved in immune response [ISS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- platelet-derived growth factor receptor signaling pathway [ISS, TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- regulation of lamellipodium assembly [IDA]
- regulation of mast cell degranulation [IBA]
- regulation of protein phosphorylation [ISS]
- response to lipopolysaccharide [ISS]
- response to platelet-derived growth factor [ISS]
- substrate adhesion-dependent cell spreading [ISS]
- tyrosine phosphorylation of Stat3 protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTK2
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
protein tyrosine kinase 2
GO Process (42)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- angiogenesis [IBA, TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell motility [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytoskeleton organization [IBA]
- embryo development [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of cell polarity [TAS]
- growth hormone receptor signaling pathway [IDA]
- heart morphogenesis [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IDA, IMP, TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell-cell adhesion [IDA]
- netrin-activated signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- placenta development [TAS]
- platelet activation [TAS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- protein autophosphorylation [IDA]
- regulation of Rho GTPase activity [TAS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of cell proliferation [IMP]
- regulation of cell shape [IMP]
- regulation of cytoskeleton organization [TAS]
- regulation of endothelial cell migration [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of osteoblast differentiation [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.65)
- MCF7 cell line (score 0.675)
- MDA231 cell line (score 0.663)
Curated By
- BioGRID