A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Bub3p facilitates spindle checkpoint silencing in fission yeast.

Vanoosthuyse V, Meadows JC, van der Sar SJ, Millar JB, Hardwick KG

Although critical for spindle checkpoint signaling, the role kinetochores play in anaphase promoting complex (APC) inhibition remains unclear. Here we show that spindle checkpoint proteins are severely depleted from unattached kinetochores in fission yeast cells lacking Bub3p. Surprisingly, a robust mitotic arrest is maintained in the majority of bub3 Delta cells, yet they die, suggesting that Bub3p is essential for ... [more]

Mol. Biol. Cell Dec. 01, 2009; 20(24);5096-105 [Pubmed: 19846658]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

PSC3

Gene Ontology Biological Process

Gene Ontology Cellular Component

BUB3