BAIT
KIF5B
HEL-S-61, KINH, KNS, KNS1, UKHC
kinesin family member 5B
GO Process (10)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- ATP catabolic process [IBA]
- axon guidance [IBA]
- cellular protein metabolic process [TAS]
- cytoskeleton-dependent intracellular transport [IBA]
- microtubule-based movement [IBA]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of potassium ion transport [IDA]
- regulation of membrane potential [IDA]
- stress granule disassembly [ISS]
- vesicle transport along microtubule [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MRE11A
ATLD, HNGS1, MRE11, MRE11B
MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
GO Process (22)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA duplex unwinding [IMP]
- DNA recombination [TAS]
- DNA repair [TAS]
- base-excision repair [IBA]
- cellular response to DNA damage stimulus [IDA]
- double-strand break repair [IBA, TAS]
- double-strand break repair via homologous recombination [TAS]
- double-strand break repair via nonhomologous end joining [TAS]
- innate immune response [TAS]
- intra-S DNA damage checkpoint [IBA]
- negative regulation of DNA endoreduplication [IMP]
- nucleic acid phosphodiester bond hydrolysis [IBA, TAS]
- nucleotide-excision repair [IBA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of type I interferon production [TAS]
- reciprocal meiotic recombination [TAS]
- regulation of mitotic recombination [TAS]
- sister chromatid cohesion [IMP]
- telomere maintenance [IBA]
- telomere maintenance via telomerase [TAS]
Gene Ontology Molecular Function- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
- 3'-5' exonuclease activity [IBA]
- ATP-dependent DNA helicase activity [IMP]
- DNA binding [IDA]
- double-stranded DNA binding [TAS]
- endodeoxyribonuclease activity [TAS]
- endonuclease activity [IBA]
- nuclease activity [TAS]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- single-stranded DNA endodeoxyribonuclease activity [TAS]
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF7 cell line (score 0.701)
Curated By
- BioGRID