BAIT
CCT6A
CCT-zeta, CCT-zeta-1, CCT6, Cctz, HTR3, MoDP-2, TCP-1-zeta, TCP20, TCPZ, TTCP20
chaperonin containing TCP1, subunit 6A (zeta 1)
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RCC2
TD-60
regulator of chromosome condensation 2
GO Process (10)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- chromosome passenger complex localization to kinetochore [IMP]
- focal adhesion assembly [IDA]
- integrin-mediated signaling pathway [IDA]
- mitotic cell cycle [TAS]
- negative regulation of GTPase activity [ISS]
- negative regulation of focal adhesion assembly [ISS]
- negative regulation of substrate adhesion-dependent cell spreading [ISS]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of attachment of spindle microtubules to kinetochore [IMP]
- regulation of cell migration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.638)
Curated By
- BioGRID