BAIT
PRKCI
DXS1179E, PKCI, nPKC-iota
protein kinase C, iota
GO Process (21)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- cell junction assembly [TAS]
- cell-cell junction organization [IMP, TAS]
- cellular response to insulin stimulus [ISS]
- cytoskeleton organization [NAS]
- establishment or maintenance of epithelial cell apical/basal polarity [TAS]
- membrane organization [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of glial cell apoptotic process [IMP]
- negative regulation of neuron apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of endothelial cell apoptotic process [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glial cell proliferation [IMP]
- positive regulation of glucose import [ISS]
- positive regulation of neuron projection development [IMP]
- protein phosphorylation [IDA]
- protein targeting to membrane [NAS]
- secretion [NAS]
- tight junction assembly [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CPSF6
CFIM, CFIM68, HPBRII-4, HPBRII-7
cleavage and polyadenylation specific factor 6, 68kDa
GO Process (3)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MDA231 cell line (score 0.641)
Curated By
- BioGRID