BAIT
CAPZB
CAPB, CAPPB, CAPZ, RP4-657E11.7
capping protein (actin filament) muscle Z-line, beta
GO Process (7)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TAOK3
DPK, JIK, MAP3K18
TAO kinase 3
GO Process (11)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- mitotic G2 DNA damage checkpoint [IMP]
- negative regulation of JNK cascade [IDA]
- negative regulation of protein kinase activity [TAS]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IMP]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, IMP]
Gene Ontology Molecular Function
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.626)
Curated By
- BioGRID