BAIT
ROCK1
P160ROCK, ROCK-I
Rho-associated, coiled-coil containing protein kinase 1
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte migration [IDA]
- leukocyte tethering or rolling [IDA]
- membrane to membrane docking [IDA]
- myoblast migration [ISS]
- negative regulation of angiogenesis [IMP]
- positive regulation of focal adhesion assembly [ISS]
- regulation of actin cytoskeleton organization [TAS]
- regulation of cell adhesion [TAS]
- regulation of cell motility [TAS]
- regulation of establishment of cell polarity [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of keratinocyte differentiation [IMP]
- regulation of stress fiber assembly [TAS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
IL18
IGIF, IL-18, IL-1g, IL1F4
interleukin 18
GO Process (24)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- MAPK cascade [IMP]
- T-helper 1 type immune response [IDA]
- angiogenesis [IDA]
- cell-cell signaling [TAS]
- cellular response to organic cyclic compound [IDA]
- chemokine biosynthetic process [TAS]
- granulocyte macrophage colony-stimulating factor biosynthetic process [TAS]
- immune response [TAS]
- inflammatory response [IDA]
- interferon-gamma biosynthetic process [TAS]
- interleukin-13 biosynthetic process [TAS]
- interleukin-2 biosynthetic process [TAS]
- lipopolysaccharide-mediated signaling pathway [IDA]
- positive regulation of NK T cell proliferation [IDA]
- positive regulation of activated T cell proliferation [IDA]
- positive regulation of granulocyte macrophage colony-stimulating factor production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-17 production [IDA]
- positive regulation of natural killer cell proliferation [IDA]
- positive regulation of tissue remodeling [IC]
- regulation of cell adhesion [IDA]
- sleep [ISS]
- type 2 immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF10A cell line (score 0.688)
Curated By
- BioGRID