BAIT

DCTN1

DAP-150, DP-150, P135

dynactin 1

Parkinson's Disease Project

GO Process (9)

GO Function (1)

GO Component (8)

Gene Ontology Biological Process

G2/M transition of mitotic cell cycle [TAS]

activation of signaling protein activity involved in unfolded protein response [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]

cellular protein metabolic process [TAS]

endoplasmic reticulum unfolded protein response [TAS]

mitotic cell cycle [TAS]

mitotic nuclear division [NAS]

nervous system development [NAS]

retrograde transport, endosome to Golgi [IMP]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

centrosome [IDA]

cytoplasm [TAS]

kinetochore [IDA]

microtubule [IDA]

retromer complex [IDA]

spindle pole [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

RNF14

ARA54, HFB30, TRIAD2, HRIHFB2038

ring finger protein 14

GO Process (8)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

androgen receptor signaling pathway [NAS]

positive regulation of transcription, DNA-templated [IDA, NAS]

protein ubiquitination [IEP]

regulation of androgen receptor signaling pathway [IDA]

regulation of transcription from RNA polymerase II promoter [TAS]

regulation of transcription, DNA-templated [IDA]

response to estradiol [IDA]

signal transduction [TAS]

Gene Ontology Molecular Function

androgen receptor binding [IPI]
protein binding [IPI]
small conjugating protein transferase activity [IDA]
transcription coactivator activity [NAS, TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Havugimana PC, Goel RK, Phanse S, Youssef A, Padhorny D, Kotelnikov S, Kozakov D, Emili A

Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]

Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]

Throughput

High Throughput

Additional Notes

High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
MCF7 cell line (score 0.66)

Curated By

BioGRID