BAIT
ERC1
Cast2, ELKS, ERC-1, RAB6IP2
ELKS/RAB6-interacting/CAST family member 1
GO Process (5)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PYCARD
ASC, CARD5, TMS, TMS-1, TMS1
PYD and CARD domain containing
GO Process (48)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [NAS]
- activation of innate immune response [IDA]
- apoptotic process [TAS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to tumor necrosis factor [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to virus [IDA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- macropinocytosis [ISS]
- myeloid dendritic cell activation [IMP]
- myeloid dendritic cell activation involved in immune response [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of interferon-beta production [IMP]
- negative regulation of protein serine/threonine kinase activity [IDA]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell migration [ISS]
- positive regulation of actin filament polymerization [ISS]
- positive regulation of activated T cell proliferation [ISS]
- positive regulation of adaptive immune response [IMP]
- positive regulation of antigen processing and presentation of peptide antigen via MHC class II [ISS]
- positive regulation of apoptotic process [IDA]
- positive regulation of chemokine secretion [IMP]
- positive regulation of cysteine-type endopeptidase activity [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of extrinsic apoptotic signaling pathway [IDA]
- positive regulation of interferon-gamma production [ISS]
- positive regulation of interleukin-1 beta secretion [IDA]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-6 production [ISS]
- positive regulation of interleukin-6 secretion [IMP]
- positive regulation of interleukin-8 secretion [IMP]
- positive regulation of phagocytosis [ISS]
- positive regulation of release of cytochrome c from mitochondria [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of tumor necrosis factor production [IMP]
- regulation of intrinsic apoptotic signaling pathway [IDA]
- regulation of protein stability [ISS]
- regulation of tumor necrosis factor-mediated signaling pathway [IMP]
- signal transduction [NAS]
- tumor necrosis factor-mediated signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MDA231 cell line (score 0.679)
Curated By
- BioGRID