BAIT
DIS3L2
FAM6A, PRLMNS, hDIS3L2
DIS3 like 3'-5' exoribonuclease 2
GO Process (9)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis [IDA]
- RNA phosphodiester bond hydrolysis, exonucleolytic [IDA]
- miRNA catabolic process [IDA, ISS]
- mitotic nuclear division [IMP]
- mitotic sister chromatid separation [IMP]
- negative regulation of cell proliferation [IMP]
- nuclear-transcribed mRNA catabolic process, exonucleolytic [IMP]
- polyuridylation-dependent mRNA catabolic process [ISS]
- stem cell maintenance [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CDK5RAP3
C53, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114, PP1553, MSTP016
CDK5 regulatory subunit associated protein 3
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Co-fractionation/mass spectrometry (CF/MS) enables the mapping of endogenous macromolecular networks on a proteome scale, but current methods are experimentally laborious, resource intensive and afford lesser quantitative accuracy. Here, we present a technically efficient, cost-effective and reproducible multiplex CF/MS (mCF/MS) platform for measuring and comparing, simultaneously, multi-protein assemblies across different experimental samples at a rate that is up to an order ... [more]
Nat Commun Jul. 13, 2022; 13(1);4043 [Pubmed: 35831314]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an EPIC score >=0.625 in applicable cell lines (MCF7, MDA231 or MCF10A)
- MCF7 cell line (score 0.675)
Curated By
- BioGRID