BAIT
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
GO Process (44)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [ISO]
- JNK cascade [IMP]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [ISO]
- bone remodeling [ISO]
- bone resorption [ISO]
- cell development [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [IMP]
- immune response [ISO]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [ISO]
- odontogenesis of dentin-containing tooth [ISO]
- organ morphogenesis [ISO]
- ossification [ISO]
- osteoclast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO]
- protein complex assembly [IMP]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of immunoglobulin secretion [ISO]
- response to interleukin-1 [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAP3K7
Tak1
mitogen activated protein kinase kinase kinase 7
GO Process (22)
GO Function (7)
GO Component (7)
Gene Ontology Biological Process
- I-kappaB phosphorylation [ISO, ISS]
- JNK cascade [ISO]
- MAPK cascade [IDA, ISO]
- activation of MAPK activity [ISO]
- activation of MAPKK activity [IDA, ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- angiogenesis [ISO]
- histone H3 acetylation [ISO]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of necroptotic process [ISO]
- negative regulation of reactive oxygen species metabolic process [ISO]
- negative regulation of ripoptosome assembly involved in necroptotic process [ISO]
- neural tube formation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [ISO, ISS]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of interleukin-2 production [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of reactive oxygen species metabolic process [ISO]
- stress-activated MAPK cascade [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Tabersonine attenuates Angiotensin II-induced cardiac remodeling and dysfunction through targeting TAK1 and inhibiting TAK1-mediated cardiac inflammation.
Angiotensin II (Ang II)-induced cardiac inflammation contribute to pathological cardiac remodeling and hypertensive heart failure (HF). Tabersonine (Tab) is an indole alkaloid mainly isolated from Catharanthus roseus and exhibits anti-inflammatory activity in various systems. However, the role of Tab in hypertensive HF and its molecular targets remains unknown.We aimed to investigate potential cardioprotective effects and mechanism of Tab against Ang ... [more]
Phytomedicine Aug. 01, 2022; 103();154238 [Pubmed: 35696800]
Throughput
- Low Throughput
Curated By
- BioGRID