BAIT
HERC5
CEB1, CEBP1
HECT and RLD domain containing E3 ubiquitin protein ligase 5
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- ISG15-protein conjugation [IDA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of type I interferon production [TAS]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of defense response to virus [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
NEDD8
NEDD-8
neural precursor cell expressed, developmentally down-regulated 8
GO Process (6)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.
This study aims to find differentially expressed ubiquitination-related gene(s) and elucidates their biological significance in breast cancer.Differentially expressed genes were profiled in MCF-7 and MDA-MB-231 cells by using PCR array method. Abnormal expression of HERC5 was studied in the cells and in breast cancer specimens via Quantitative Real-time PCR and western blot. Cell proliferation and cell migration abilities were evaluated ... [more]
Life Sci Aug. 15, 2022; 303();120692 [Pubmed: 35671810]
Throughput
- Low Throughput
Curated By
- BioGRID